Table 1 Breast cancer exosome proteins identified by cancer biomarker antibody array. Proteins identified in either group with a fold-change ≥1.5 (MCF7 vs. MCF10A), p < 0.05 (Student’s T test) are listed and grouped by molecular function
Protein Name | Swiss Prot | Fold Change | P-value | Protein Name | Swiss Prot | Fold Change | P-value |
|---|---|---|---|---|---|---|---|
Signaling molecules (cytokines, growth factors, and peptide hormones) | Cytoskeletal proteins | ||||||
 Myostatin | O14793 | 21,111.91 | 2.29E-10 |  Tubulin gamma | P23258 | 754.10 | 1.93E-13 |
 FSH | P01225 | 15,362.78 | 4.48E-11 |  Tubulin beta | Q13509 | 450.98 | 6.32E-11 |
 IL-15 | P40933 | 8289.69 | 9.00E-12 |  Beta actin |  | 2.77 | 2.80E-09 |
 IGF-II | P01344 | 1935.77 | 4.89E-12 |  Tubulin alpha | Q71U36 | 1.89 | 2.78E-02 |
 VEGFB | P49765 | 1535.45 | 1.51E-10 | Protease inhibitor | |||
 IL-12 | P29459 | 1072.56 | 1.28E-09 |  ACT | P01011 | 1573.14 | 2.07E-11 |
 MIP-3β/CCL19 | Q99731 | 838.61 | 1.36E-12 |  TIMP-1 | P01033 | 1296.86 | 2.69E-10 |
 TGFβ2 | P61812 | 691.68 | 7.88E-15 |  PAI-1/SERPINE1 | P05121 | 0.00007 | 1.50E-08 |
 PDGFB | P01127 | 365.81 | 8.82E-13 | DNA Binding Protein | |||
 Mammaglobin B | O75556 | 285.27 | 7.06E-04 |  MLL/KMT2A | Q03164 | 402.38 | 6.22E-17 |
 Osteopontin | P10451 | 262.26 | 7.16E-04 |  MSH2 | P43246 | 175.50 | 1.15E-12 |
 IL-17E | Q9H293 | 226.68 | 1.56E-12 |  MTA1 | Q13330 | 168.22 | 1.51E-16 |
 IGF-I | P05019 | 174.44 | 4.99E-02 | Cell Adhesion Molecules | |||
 IL-17F | Q96PD4 | 171.53 | 1.00E-11 |  CEA | P06731 | 4423.56 | 1.96E-11 |
 TNF-alpha | P01375 | 107.92 | 5.67E-04 |  VCAM-1 | P19320 | 573.18 | 4.07E-11 |
 TGF alpha | P01135 | 81.47 | 4.95E-02 |  ALCAM | Q13740 | 344.25 | 3.76E-14 |
 IL-13 | P35225 | 0.0004 | 1.02E-02 |  ITGB2/CD18 | P05107 | 0.12 | 1.31E-03 |
 NGF | P01138 | 0.08 | 6.23E-13 |  TSP1 | P07996 | 0.03 | 1.05E-15 |
 Resistin | Q9HD89 | 0.05 | 8.90E-13 | Transfer/Carrier Protein | |||
 RANTES/CCL5 | P13501 | 0.0002 | 3.28E-10 |  ALB | P02768 | 165.05 | 3.77E-12 |
 EGF | P01133 | 0.0002 | 5.66E-04 |  AFP | P02771 | 14,293.40 | 3.98E-11 |
Hydrolase/Protease | Extracellular Matrix Protein | ||||||
 PSA | P07288 | 7771.26 | 5.22E-15 |  COL4A1 | P02462 | 2326.71 | 2.49E-06 |
 MMP-10 | P09238 | 7395.53 | 1.10E-10 |  Laminin |  | 387.50 | 1.24E-13 |
 MMP-2 | P08253 | 4044.93 | 2.41E-06 |  COL3A1 | P02461 | 320.58 | 3.22E-09 |
 MMP-19 | Q99542 | 298.36 | 3.60E-11 |  ITGA5 | P08648 | 131.46 | 9.71E-12 |
 MMP-7 | P09237 | 186.87 | 1.07E-02 |  Fibronectin | P02751 | 0.26 | 8.82E-13 |
 MMP-11 | P24347 | 42.32 | 1.10E-10 | Oxidoreductase | |||
Cytokine receptor |  MPO | P05164 | 419.24 | 3.16E-10 | |||
 TGFBR3 | Q03167 | 902.09 | 3.53E-09 | Defense/Immunity Protein | |||
 TGFBR2 | P37173 | 295.19 | 1.09E-08 |  B2M | P61769 | 0.060 | 8.91E-13 |
 IL2RA | P01589 | 0.01 | 6.00E-10 |  IgA |  | 0.067 | 8.99E-11 |
Growth Factor Receptor | Storage Protein | ||||||
 CD40LR | P25942 | 519.22 | 1.08E-12 |  Ferritin | P02794 | 1414.57 | 3.53E-13 |
 Tek/Tie2 | Q02763 | 402.05 | 1.21E-10 | Transcription Factor | |||
 TYRO3 | Q06418 | 245.33 | 5.91E-04 |  THR alpha | P10827 | 1164.74 | 1.75E-14 |
 NTRK1/TrkA | P04629 | 236.47 | 6.48E-14 | Transferase/Kinase | |||
 PDGFR alpha | P16234 | 204.86 | 5.11E-11 |  Tyk2 | P29597 | 15,893.91 | 8.85E-16 |
DNA Repair Protein | |||||||
 MUM1 | Q2TAK8 | 632.43 | 5.45E-04 | ||||