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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells

Fig. 7

Oroxylin A alleviates liver injury and fibrosis by targeting LDH-A in mice intoxicated with CCl4. Animal grouping and treatments refer to the Methods section. a Measurements of liver/body weight ratio. b Measurements of serum levels of ALT and AST. c Measurements of serum levels of TBIL and IBIL. d Measurements of serum levels of HA, LN and PC-III. e Measurements of hepatic Hyp contents. f H&E staining, Masson staining, Sirius red staining, and immunohistochemical analysis of α-SMA in liver tissues, scale bar: 100 μm. g Real-time PCR analyses of mRNA expression of α-SMA, fibronectin and α1(I) procollagen in liver tissues. h Western blot analyses of protein expression of α-SMA, fibronectin and α1(I) procollagen in liver tissues with quantification. i SEM analyses of sinusoidal fenestration indicated by white arrows, scale bar: 2 μm. For statistical significance of this figure: **p < 0.01 vs. control, ***p < 0.001 vs. control; #p < 0.05 vs. CCl4, ##p < 0.01 vs. CCl4; &p < 0.05 vs. CCl4 + oroxylin A + adenovirus vector

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