Fig. 8
From: Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis
Model of c-Abl regulation in Hp-infected cells. Hp induces tyrosine and threonine phosphorylation of c-Abl. Tyrosine phosphorylation leads to c-Abl kinase activation. Threonine 735 phosphorylation is directly mediated by PKC and forces cytoplasmic localization of c-Abl via binding to 14–3-3 proteins. Cytoplasmic retention of activated c-Abl promotes cell elongation and migration contributing to the EMT-like phenotype and attenuates apoptotic functions in the nucleus