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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis

Fig. 7

Hp induces pAblT735 phosphorylation and activation to promote pathogenesis in vivo. (a) Tissue samples from healthy (control), type-C gastritis and Hp-mediated gastritis patients were stained with hematoxylin and antibodies recognizing c-Abl or pAblT735. (b) Histology scores of the analyzed sections were evaluated for Abl and pAblT735 in the epithelium and gastric glands. (c) C57BL/6 mice were infected with PMSS1 for two months and remained untreated (ctrl) or were supplied with STI-571. Gastric tissue sections were analyzed for chronic inflammation, gastric atrophy, intestinal metaplasia and mucus pit cell/epithelial hyperplasia (left panel). Mice were analyzed for Hp colonization using cfu assays (right panel). Box blots show median, 25th and 75th percentile (box) and 5th and 95th percentile (whiskers)

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