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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Low dose radiation regulates BRAF-induced thyroid cellular dysfunction and transformation

Fig. 7

LDR suppresses the thyroid cancer carcinogenesis through STAT3-miR-330-5p axis. During thyroid cell malfunction, miR-144-3p/miR-330-5p degrades the PAX8 mRNA levels, thereby blocks its activity to NIS, TG and TSHR promoters. However, LDR treatment decreases the PAX8 targeting miRNAs expression and eventually recovers the PAX8 activity on its target gene promotes to improve thyroid cell function in cancer cells

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