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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway

Fig. 7

A schematic model showing the effects of duodenal ghrelin on hepatic glucose fluxes and insulin signals. Ghrelin binds to its receptor, GHS-R1a, on the duodenum and inhibits mucosal AMPK. This signal is delivered to the NTS by vagus afferent nerve and activates the neurons in hindbrain region and NMDA receptors. Finally, the signal is relayed from the NTS to the liver via the efferent branch of the vagal nerve to increase HGP and inhibit insulin signal

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