Fig. 3
From: Extracellular vesicles in bone: “dogrobbers” in the “eternal battle field”
‘Micro-damage-driven’ remodelling orchestrated by OYs via sclerostin. OYs are responsible for directly sensing ‘damage’ that interrupts the canaliculi. Sclerostin has been reported to maintain the status ‘inhibition of OB differentiation’. However, mechanical loading or ‘damage’ would shut down sclerostin, causing a loss of efficacy of the ‘inhibition of OB differentiation’ function; in other words, increasing OB differentiation and bone mass