Fig. 2
From: Extracellular vesicles in bone: “dogrobbers” in the “eternal battle field”
Constituents of EVs. EVs are composed of lipid bilayers, membrane proteins, intravesicular proteins, DNA, messenger RNAs (mRNAs), microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). The lipid bilayers provide protection from the complex and potentially harmful body fluid environment to the bioactive substances within EVs, the membrane proteins give EVs targeting abilities, and the various intravesicular contents give EVs the ability to transmit multidimensional, abundant and complicated information