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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Overexpression of MTA1 inhibits the metastatic ability of ZR-75-30 cells in vitro by promoting MTA2 degradation

Fig. 6

486, 497, 542, 583 and 621 sites were identified to be NE cleavage sites of MTA2. a Schematic diagram of the predicted 9 NE cleavage sites after 461 locating in MTA2 C-terminus. b Identification of 486, (c) 497 (d) 542, 583 and (e) 621 as NE cleavage sites. f Unpredicted NE cleavage site(s) may locate between 621 and 643 sites. g MTA2-N-624-I486GI497GI542GI583GT621G-HA, designated as MTA2-N-624-5smut-HA was overexpressed in ZR-75-30 cells. h Overexpression of MTA2-N-624-5smut-HA significantly promoted the migration and (i) invasion of ZR-75-30-MTA1 cells. Scale bars = 200 μm, mean ± SD, n = 3,***P < 0.001, t test. j MTA2-N-486-HA showed a tendency of diffusing into cytoplasm. Scale bars = 25 μm

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