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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Overexpression of MTA1 inhibits the metastatic ability of ZR-75-30 cells in vitro by promoting MTA2 degradation

Fig. 5

NE cleavage site(s) locate(s) in MTA2 at its C terminus. a FLAG-tagged MTA1 downregulated HA-tagged MTA2 in 293FT cells. b The expression of MTA1-FLAG did not decrease the mRNA level of MTA2-HA in 293FT cells. Mean ± SD, n = 3, t test. c Schematic diagram of the constructed C-terminal truncated mutants of MTA2 fused with HA tag. The full length of MTA2 contains 668aa. The C-terminal truncated mutant from 147aa to 668aa fused with HA tag was designated as MTA2-C-147-HA, and the rest were designated in a similar fashion. d MTA1-FLAG downregulated all 4 C-terminal truncated mutants of MTA2. e Schematic diagram of the constructed MTA2 N-terminal truncated mutants. f MTA2-N-201-HA, MTA2-N-312-HA and (g) MTA2-N-462-HA instead of MTA2-N-497-HA and longer N-terminal truncated mutants of MTA2 could not be downregulated by MTA1-FLAG

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