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Table 2 Exosomal cargos detected in HCC and their target and clinical relevance

From: Exosomes in hepatocellular carcinoma: a new horizon

Exosomal cargos Target Biological/clinical relevance Reference
(1) miRNA
 miRNA TAK1 Facilitated tumorigenesis [104]
 miR-1247-3p B4GALT3 Converted normal fibroblasts to cancer-associated fibroblasts (CAFs) [114]
 miR-122   Suppressed HCC cells growth and proliferation [115]
 miR-320a PBX3 Suppressed CAFs proliferation [118]
 miR-335-5p   Inhibited HCC cells proliferation [119]
 miR451,miR223, miR24,miR125b miR31,and miR122   Inhibited HCC cells growth and stimulated apoptosis [120]
 miR-103   Facilitated tumor metastasis [122]
 miR-32-5p PTEN Induced multidrug resistance in Bel7402 cells [131]
(2) lncRNA
 lncRNA H19   Promoted angiogenesis [109]
 TUC339   Promoted HCC proliferation and spread [116]
 linc-RoR miR-145 Increased HCC cells viability and promoted HCC cells survival [117]
 lncRNA FAL1 miR-1236 Promoted Huh7 and HepG2 cells proliferation and metastasis [123]
 linc-VLDLR ABCG2 Leaded to acquired chemoresistance in HCC cells [133]
(3) Proteins
 proteins   Facilitated tumorigenesis in normal hepatocytes [106]
 Vasorin   Promoted angiogenesis [108]
  1. TAK1 transforming growth factorβactivated kinase-1, B4GALT3 β-1,4-galactosyltransferases, PTEN phosphatase and tensin homolog, PBX3 pre-B-cell leukemia transcription factor 3, ABCG2 ATP-binding cassette, sub-family G member 2