Exosomal cargos | Target | Biological/clinical relevance | Reference |
---|---|---|---|
(1) miRNA | |||
 miRNA | TAK1 | Facilitated tumorigenesis | [104] |
 miR-1247-3p | B4GALT3 | Converted normal fibroblasts to cancer-associated fibroblasts (CAFs) | [114] |
 miR-122 |  | Suppressed HCC cells growth and proliferation | [115] |
 miR-320a | PBX3 | Suppressed CAFs proliferation | [118] |
 miR-335-5p |  | Inhibited HCC cells proliferation | [119] |
 miR451,miR223, miR24,miR125b miR31,and miR122 |  | Inhibited HCC cells growth and stimulated apoptosis | [120] |
 miR-103 |  | Facilitated tumor metastasis | [122] |
 miR-32-5p | PTEN | Induced multidrug resistance in Bel7402 cells | [131] |
(2) lncRNA | |||
 lncRNA H19 |  | Promoted angiogenesis | [109] |
 TUC339 |  | Promoted HCC proliferation and spread | [116] |
 linc-RoR | miR-145 | Increased HCC cells viability and promoted HCC cells survival | [117] |
 lncRNA FAL1 | miR-1236 | Promoted Huh7 and HepG2 cells proliferation and metastasis | [123] |
 linc-VLDLR | ABCG2 | Leaded to acquired chemoresistance in HCC cells | [133] |
(3) Proteins | |||
 proteins |  | Facilitated tumorigenesis in normal hepatocytes | [106] |
 Vasorin |  | Promoted angiogenesis | [108] |