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Table 1 Serum exosomal-derived biomarker studies in HCC

From: Exosomes in hepatocellular carcinoma: a new horizon

Biomarkers (expression) Method Cohort (patients) Clinical significance References
(1) mRNA
 hn-RNPH1
 mRNA↑
Taqman real-time PCR 68 HCC vs 67 LC vs 68 CHB vs 68 healthy control Diagnostic biomarker for dividing HCC and CHB [96]
(2) miRNA
 miR-718↓ qRT-PCR 59 HCC Predicting biomarker for recurrence afer LT [97]
 miR-18a↑
 miR-221↑
 miR-222↑
 miR-224↑
qRT-PCR 30 HCC vs 30 CHB vs 30 healthy controls Diagnostic biomarker for dividing HCC and CHB [99]
 miR-101↓
 miR-106b↓
 miR-122↓
 miR-195↓
qRT-PCR 20 HCC vs 20 CHB vs 20 LC Diagnostic biomarker for dividing HCC and CHB [99]
 MiR-125b↑ qRT-PCR 158 HCC vs 30 CHB vs 30 LC Predicting biomarker for recurrence and survival [100]
 miR-122↑
 miR-148a↑
 miR-124b↑
qPCR 5 HCC vs 5 LC Diagnostic biomarker for dividing HCC and LC [101]
 miR-122↑
 miR-148a↑
 AFP↑
qPCR 5 HCC vs 5 LC Diagnostic biomarker for dividing HCC and LC [101]
 miR-122↑ qPCR 5 HCC vs 5 LC Diagnostic biomarker for dividing HCC and healthy [101]
(3) lncRNA
 lncRNA-HEIH↑ qRT-PCR 35 HCC vs HCV-induced
Cirrhosis vs 10 HCV-induced
HCC
Diagnostic biomarker for dividing HCC and CHC [102]
 ENSG00000258332.1↑
 LINC00635↑
Taqman
PCR
60 HCC vs 85 LC vs 96 CHB vs 60 healthy subjects Diagnostic biomarker for dividing HCC and CHB and LC [103]
  1. CHC chronic hepatitis C, CHB chronic hepatitis B, HCV hepatitis C virus, LC liver cirrhosis, LT liver transolantation, qRT-PCR quantitative reverse transcription polymerase chain reaction, qPCR quantitative polymerase chain reaction, AFP alpha-fetoprotein