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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway

Fig. 4

Effect of Cori treatment on Keap1-Nrf2 signaling pathway in HepG2 cells. HepG2 cells were subjected to Cori (30 μM) for 3 h, subsequently stimulated with and without APAP (15 mM) for 3 h. Effects of Cori on Nrf2, GCLC, GCLM, NQO1, HO-1 and Keap1 protein expression. The relative density of protein was performed by densitometric analysis; β-actin was acted as an internal control. Similar results were obtained from three independent experiments. All results were expressed as means ± SEM of three independent experiments. #p < 0.05, ##p < 0.01 vs the Control group; *p < 0.05, **p < 0.01 vs the APAP group

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