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Fig. 10 | Cell Communication and Signaling

Fig. 10

From: Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway

Fig. 10

Protective effects of Cori-meditated Nrf2 on APAP-induced mice with ALF. WT and Nrf2 −/− mice (n = 15 /group) were intraperitoneally injected Cori (60 mg/kg) with mice for twice at a 12 h (interval for 12 h), followed by subjected treatment with APAP (900 mg/kg). a The survival rates of the mice were observed within 48 h after APAP exposure. Moreover, (b-c) serum was collected from the mice after exposure to APAP (400 mg/kg) for 6 h for measurement of the ALT and AST levels. (d) Livers (n = 5) from each experimental group were processed for histological evaluation at 6 h after the APAP (400 mg/kg) challenge. Similar results were obtained from three independent experiments. All data are presented as means ± SEM (n = 5/group). ##p < 0.01 vs. Control group; *p < 0.05, **p < 0.01 vs. APAP group

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