Fig. 1

Effect of Cori treatment on APAP-induced hepatotoxicity in HepG2 cells. a Chemical structure of corilagin (Cori). b HepG2 cells were treated by Cori (0, 3.75, 7.5, 15, 30, or 60 μM) for 24 h. Cell viability was measured by CCK8 assay. c Cells were subjected to Cori (7.5, 15 or 30 μM) for 1 h, and then exposed to APAP (15 mM) for 24 h. Cell viability was determined by CCK8 assay. Moreover, (d-e) the ROS generation was measured according to the Experimental Section and determined by a fluorescent microscope. Similar results were obtained from three independent experiments. All results were expressed as means ± SEM of three independent experiments. ^##p < 0.01 vs the Control group; ^*p < 0.05, ^**p < 0.01 vs the APAP group