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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression

Fig. 7

High PLOD2 expression is closely correlated with poor prognosis of breast cancer and closely relates to GP130 and OBR in clinical samples. a Kaplan-Meier analysis of relapse-free survival (RFS) in breast cancer patients. PLOD2 in all breast cancer patients (n = 1975), in luminal A breast cancer patients (n = 966), in luminal B breast cancer patients (n = 575), and in basal-like breast cancer patients (n = 309). b Expression of PLOD2 was analyzed by immunohistochemistry (IHC) in breast cancer specimens of different subtypes and in para-cancerous specimens. Para-cancerous tissue is defined as tissue 2 cm away from the tumor tissue. Scale bars, 50 μm. c Scatter plots showing the staining index of PLOD2 in 105 breast cancer specimens. d Kaplan-Meier analysis of relapse-free survival (RFS) curve in breast cancer patients with different stages status breast cancer. e Scatter plots showing the staining index of PLOD2 in different stages status breast cancer. f, g Expression level of GP130, OBR and PLOD2 were consistently analyzed in 71 breast cancer specimens (Excluding 4 broken specimens). Scale bars, 50 μm

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Cell Communication and Signaling

ISSN: 1478-811X