Fig. 9
From: Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila
Model of the functions of Jumu in filopodium formation and circulating hemocyte phagocytosis. a Normal expression of Jumu maintains the levels of NimC1, Enabled and Fascin in a direct or indirect manner. Enabled and Fascin participate in filopodium formation. The phagocytosis receptor NimC1 is involved in the recognition of pathogens and the subcellular localization of Ena. b Deficiency of Jumu reduces the protein levels of NimC1, Enabled and Fascin and consequently inhibits filopodium formation and hemocyte phagocytosis. c Severe deficiency of jumu can inhibit normal hemocyte mitosis and result in enlarged multinucleated hemocytes. The loss of jumu may control the cell cycle and mitosis process by affecting the expression of the Cyclin genes png and piwi. Severe deficiency of jumu also induces the generation of lamellocytes through the activation of the Toll signaling pathway