Fig. 3

High IMPACT appears to ameliorate stress response when tryptophan dioxygenases are upregulated in prostate adenocarcinoma. a) Scatter plots between the expression of IMPACT (y-axis), GCN2 pathway genes (EIF2AK4, ATF4, DDIT3), mTOR pathway genes (MTOR, RPS6KB1) and β-actin within the TCGA prostate adenocarcinoma cohort. P and r indicates statistical significance and correlation coefficient, respectively. Marginal grey lines represent histograms. b) Inter-gene correlations and differential expression of genes from Fig. 2 in prostate adenocarcinoma (left) and non-cancer prostate tissue (right). The two grey scale vertical bars denote mean gene expression value. The middle bar next to the gene names indicates differential expression (Δ) between cancer (C) and non-cancer (N) samples. The heatmap was generated using function corplot2 from the package pcot2 [37] in R; the Manhattan distance metric was used for clustering