Fig. 2

IMPACT expression negatively correlates with expression of stress response genes in several clinical cancers. a) Spearman’s rank correlations between the expression of IMPACT and tryptophan dioxygenase genes (IDO1, IDO2, TDO2), representative genes from the GCN2 stress response pathway (DDIT3, ATF4, EIF2AK4, EIF2S1) and the mTOR pathway (MTOR, RPS6KB1), and cytoskeleton genes ACTB and TUBB as negative controls, in 28 cancer types and their 24 matching normal tissues (x-axis) classified into 20 organ categories (top panels). Colour intensity of the circles represents the magnitude of correlation and the area of circles represents statistical significance of the correlation estimated from 10⁵ random permutations adjusted for multiple comparisons using Bonferroni correction. b) Median mRNA counts for each gene within the dataset