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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis

Fig. 1

Myofibroblast differentiation of LR-MSCs occurs in pulmonary fibrogenesis. a Mice (n = 10 in each group) received either saline or bleomycin (5 mg/kg body weight) intratracheally. Mice were sacrificed 21 days later. The colocalization of Sca-1 (mesenchymal stem cell marker) and α-SMA (myofibroblast marker) was determined by immunofluorescence assay. b The colocalization of Sca-1 and α-SMA in human normal lung tissues (upper panels, n = 7) and IPF lung tissues (lower panels, n = 7) was determined by immunofluorescence assay. c and d Representative z-stack image analysis showed specific overlay of double immunostaining. Sca-1+/α-SMA+ cells in specific ordinate were analyzed in z-stack with optimal interval range of 0.8 μm

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