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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Akt1 inhibition promotes breast cancer metastasis through EGFR-mediated β-catenin nuclear accumulation

Fig. 6

Inhibition of Akt1 with MK2206 induced breast cancer metastasis through EGFR-mediated β-catenin nuclear accumulation. (a) Inhibition of Akt1 with MK2206 promotes the protein expression of p-EGFR and EGFR in MCF-7 and MDA-MB-231 cells, n = 5 per group. (b) Inhibition of Akt1 with MK2206 induced an increase in the expression of β-catenin total and nuclear protein in MCF-7 and MDA-MB-231 cells, n = 5 per group. (c) Representative photograph of metastatic lung nodules. (d) Quantification of the lung nodules. Note that a low dose of MK-2206 significantly increased the numbers of tumor metastatic nodules in tumor-bearing mice, while Gefitinib significantly reduced the number of lung metastasis in mice that received MK-2206 administration. *p < 0.05, ***p < 0.001, one-way ANOVA, n = 10 per group

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