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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia

Fig. 7

P2X7 induces nuclear translocation of TFEB. After pretreatment with compound C (10 μM) (a) or silencing of AMPK (b), BV-2 cells were stimulated with BzATP for indicated times. Cell fractionations of cytosol and nuclei were conducted and TFEB protein level was determined by immunoblotting. Data were the mean ± S.E.M. from 3 independent experiments. *p < 0.05, indicating the significant effect of BzATP. #p < 0.05, indicating the antagonistic effects of compound C and AMPK silencing on BzATP response

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