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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia

Fig. 5

P2X7 upregulates PINK and Parkin, and induces Drp1 translocation to mitochondria. a-c BV-2 cells were stimulated with BzATP (200 μM), nigericin (10 μM) or A769662 (20 μM) for indicated time periods. d and e After AMPK silence, BV-2 cells were stimulated with BzATP (d) or nigericin (e) for 1 h. Then cellular fractionations of cytosol and mitochondria were prepared. Cell lysates were subjected to SDS-PAGE for immunoblotting. Data were representative of 3 independent experiments. Data quantification was shown in Additional file 4: Figure S4

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