Fig. 7From: Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survivalInsulin attenuated Nodal-induced nuclear translocation of Smad3. INS-1 cells were treated with culture medium alone or with 100 nM insulin,in the presence or absence of 1 μg/ml Nodal for 24 h. Cells were fixed and stained with anti-Akt or anti-Smad3, and examined by fluorescence microscopyBack to article page