Skip to main content


Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection

Fig. 3

Apo-Lcn2 induces death of rat primary IMCD cells exposed to hyperosmolarity. Cells were exposed to hyperosmotic media for 7 days to increase Lcn2-R expression and incubated with 15 μg/ml apo-Lcn2 for 24 h. Cell death was determined by measuring lactate dehydrogenase (LDH) release into the medium. Means ± SEM of 4-6 experiments are shown and statistical analysis compares control versus apo-Lcn2 incubated cells by unpaired t-test. a.u. = arbitrary units

Back to article page