Fig. 3

TRPV2 regulates the Ca²⁺ influx in MM cells. a-c Kinetic curves, images and mean data demonstrating that overexpressing TRPV2 channel enhances the [Ca²⁺]_o-induced [Ca²⁺]_i elevation in LP-1. d-f Kinetic curves, images and mean data demonstrating that the inhibition of TRPV2 channel attenuates the [Ca²⁺]_o-induced [Ca²⁺]_i elevation in LP-1. g and h qRT-PCR and ELISA analyses confirming the overexpression and inhibition of TRPV2 channel influence both basal expression and high [Ca²⁺]_o-induced expression of RANKL. *P < 0.05; **P < 0.01; ***P < 0.001