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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: MSC stimulate ovarian tumor growth during intercellular communication but reduce tumorigenicity after fusion with ovarian cancer cells

Fig. 3

a Following RNA microarray analysis, changes in gene expression levels were quantified in SK-hyb1 (left panel) and SK-hyb2 cells (right panel) versus the corresponding parental cell populations SK-OV-3cherry P90 and MSC081113GFP P6, respectively. Changes in transcript levels of more than 2-fold were considered as up- or down-regulated. The entire set of microarray data is stored with the accession no. GSE117411 at the NCBI-GEO database. b Relative expression analysis based on the RNA microarray data of some characteristic mesenchymal stem-like markers was calculated for SK-OV-3 cells and the hybrid populations SK-hyb1 and SK-hyb2. For relative evaluations the expression levels of MSC were used as a control (set to 100%). c Functional changes of SK-hyb1 and SK-hyb2 cells by altered expression of telomerase (TERT) and cadherins when compared to the parental cell populations SK-OV-3cherry P90 and MSC081113GFP P6, respectively. Numbers indicate the fold changes of increased (+) or decreased (−) transcript levels

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