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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: MSC stimulate ovarian tumor growth during intercellular communication but reduce tumorigenicity after fusion with ovarian cancer cells

Fig. 2

a Tissue sections (4 μm thick) of SK-OV-3GFP control tumors and SK-OV-3GFP/MSC060616wt co-injected tumors were stained for HE and Ki67 following fixation in paraformaldehyde. A representative selection of tumor areas is shown. (Bars = 100 μm). b Ki67 positive cells in the histopathologic tissue samples were counted and the percentage was calculated in SK-OV-3GFP control tumors compared to SK-OV-3GFP/MSC060616wt co-injected tumors. Significance (p) was calculated by the mean ± s.d. using student’s t-test. c Chemotherapeutic response was tested in SK-OV-3GFP control cells and cell populations derived from tumor explant cultures of SK-OV-3GFP tumors and SK-OV-3GFP/MSC060616wt co-injected tumors. Relative proliferative capacity from steady state SK-OV-3GFP cells and the mouse tumor-derived explant populations was evaluated in a fluoroscan assay following exposure to appropriate concentrations of different chemotherapeutics for 24 h up to 72 h. Data were calculated as the mean ± s.d. (n = 5) whereby fluorescence values were set = 100% for the corresponding cells in control medium. Significance (p) was calculated using ANOVA followed by Dunnett’s multiple comparisons test

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