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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration

Fig. 2

Schematic figure depicting the key roles of menin in mTOR signaling. Initially, PDGF-BB or serum mediated activation of Akt involves PI3K-mTORC2 pathway with menin as negative regulator. Activation of S6 and eIF4B occurs in a PI3K/MAPK dependent manner, but independent of mTORC2-Akt signaling, or menin protein expression. There is a direct negative regulatory interplay between menin protein expression and the rapamycin-mediated activation of mTORC2-Akt

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Cell Communication and Signaling

ISSN: 1478-811X