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Table 3 Copper chelating compounds with anticancer activities

From: Copper signalling: causes and consequences

Compound type (name) Structure Chemical name Ligand type Application
TM Ammonium tetra-thiomolybdate Bis-Choline tetrathio molybdate Bi-dentate Breast, prostate, kidney cancer cells [208]
Trientine (TETA, Trien) N,N′-Bis(2-aminoethyl) ethane-1,2-diamine Tetra-dentate Colorectal cancer cells [366]
Hydroxyquinoline (Clioquinol) 5-Chloro-7-iodo-8-hydroxy quinoline Bi-dentate AD and human breast cancer cells [309, 316]
D-pen 3-Mercapto-D-valine Bi-dentate Human leukemia and breast cancer cells [319]
Captopril D-3-Mercapto-2-methyl-propionyl-L-proline Mammary ductal carcinoma cell line [367, 368]
Dithiocarbamates
 Disulfiram (DSF, Antabuse) 1-(Diethylthio-carbamoyl-disulfanyl)-N,N-diethyl-methane-thioamide Human breast, lung cancer cells [315, 369]
 Pyrrrolidine dithiocarbamate (PDTC) Pyrrolidine-1-carbodithioic acid Bi-dentate Human breast cancer cells [344]
Thiosemicarbazone
 Hydroxyquinoline-carboxaldehyde–Thiosemi-carbazone 8-Hydroxy-quinoline-2-carbox-aldehyde–thio-semicarbazone R = H tetra-dentate Prostate cancer cells [370]
 Retinal thiosemicarbazone 9-cis-Retinal thiosemi-carbazone Bi-dentate Human leukemic cell U937 [317]
 1,2-Bis(thiosemi-carbazones) H2gts: glyoxal-bis(thiosemi-carbazone) atsm: diacetyl-bis(4-methylthio-semi-carbazone) ptsm: pyruvaldehyde-bis(4-methylthio-semicarbazone) Tetra-dentate atsm: human colon cancer tumor cells ptsm: Ehrlich ascites and EMT6 tumour cells [371]
 Elesclomol N’1,N’3-Dimethyl-N’1,N’3-bis(phenyl-carbonothioyl)propanedihydrazide Tetra-dentate Metastatic melanoma cells [320, 331]
Schiff-bases
 Salicylaldehyde-benzoylhydrazone (SBH) N′-[(2-Hydroxyphenyl) methylidene] benzohydrazide Bi-dentate [372] Human adeno-carcinoma cell line [373]
 Salicylaldehyde-pyrazole-hydrazone (SPH) (E)- N′-(2-Hydroxy-benzylidene)-1-benzyl-3-phenyl-1H-pyrazole-5-carbohydrazide Lung carcinoma cells [321]
 Pyridine-carboxaldehyde-phenylpyrimidyl-hydrazone (Pyimpy) 1-Phenyl-1-(pyridin-2-yl)-2-(pyridin-2-ylmethylene)hydrazine Tri-dentate Rat breast tumor cells [322]
 Hydroxy naphthaldehyde imine (HL) 1-(((2-((2-Hydroxy-propyl)amino) ethyl)imino) methyl) naphthalene-2-ol) Tri-dentate Human cervical and liver hepatocellular carcinoma cells [318]