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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: A role for RASSF1A in tunneling nanotube formation between cells through GEFH1/Rab11 pathway control

Fig. 6

TNTs formation in the absence of RASSF1A is dependent on GEFH1 inactivation and Rab11 activation. a Quantification and b representative images of the TNT formation in HBEC-3 cells transfected with siNEG or siRASSF1A in combination with siGEFH1. c Quantification and d representative images of the TNT formation in HBEC-3 cells transfected with siNEG or siRASSF1A in combination with either siRab11a or siRab11b. e and g Quantification and f and h representative images of HBEC-3 cells labeled with both green and red MitoTracker dyes after RNAi treatment as indicated. Values are the mean ± SEM of three independent experiments in at least 200 cells. Statistical significance was determined by Student’s t-test and p value are indicated by asterisks: *p < 0.05; **p < 0.01; ***p < 0.001. The TNTs are show with arrowheads

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