Fig. 2
From: Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration
MB patient samples clustered based on LSD1 activity are related to patient outcomes. a, Bar graphs of expression of LSD1, REST, and USP7 in Clusters 2, 3, 4, and 5 (*p < 0.05; ****p < 0.0001). Combined expression of USP7 with Cluster 2, 3, and 4 was significantly higher than Cluster 5 (p < 0.05). b, Scatter plot of correlation of REST and LSD1 across Clusters 2–5 (r = 0.40, p < 0.0001). c, Scatter plot of correlation of LSD1 and USP7 across Clusters 2–5 (r = 0.38, p < 0.0001). d, Patient survival (Kaplan-Meier curves) associated with Clusters 2, 3, 4, and 5. Clusters 2 vs. Cluster 5 had a significant Mantel-Cox test (p < 0.05). Cluster 3 vs. Cluster 5 had a significant Mantel-Cox (p < 0.01) and Gehan-Breslow-Wilcoxon test (p < 0.05). Cluster 4 vs. Cluster 5 had a significant Mantel-Cox (p < 0.01) and Gehan-Breslow-Wilcoxon test (p < 0.05). Combined Clusters 2 and 3 vs. Cluster 5 had a significant Mantel-Cox (p < 0.05) and Gehan-Breslow-Wilcoxon test(p < 0.05). ctrl: control. e, Percentage of metastasis within each cluster