Fig. 1
From: Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration
Analysis of medulloblastoma patient samples by LSD1 expression and activity. Analysis of publicly available dataset containing 763 MB patient samples (GSE85217). a, Tukey box plots of Z-scores of LSD1 gene expression. The data points (circles) outside of the boxes represent outliers. (*p < 0.01; ***p < 0.003; ****p < 0.0001). b, Examination of patients with metastasis divided by LSD1 expression across subgroups. c, Clustering assay of SHH MB patient samples identified 6 distinct clusters based on predicted LSD1 activity. These clusters contained subtype–specific information (α, ß, δ, or Γ) provided in the bottom panel. d, Breakdown of SHH MB patient subtypes (alpha, beta, delta, gamma) per cluster (Cluster 1 n = 78; Cluster 2 n = 34; Cluster 3 n = 49; Cluster 4 n = 26; Cluster 5 n = 25; Cluster 6 n = 11)