From: Cold shock proteins: from cellular mechanisms to pathophysiology and disease
Protein | Disease | Target Cell | Mode of Action | Target Gene | Ref. |
---|---|---|---|---|---|
YB-1 | Sepsis | neutrophils, macrophages | N.D. | Toll-like receptor 4 (TLR4) CXCL-1 | [123] |
 | T-cell activation Autoimmunity Inflammation | T-helper cells | binding and stabilization of mRNA | Interleukin 2 (IL-2) | |
 | Allergic asthma | activated eosinophils | stabilization and up-regulation of mRNA transcripts | GM-CSF | [140] |
 |  | embryonic lung fibroblasts | suppression of gene transcription | GM-CSF | [205] |
 | Chronic liver disease | activated hepatic stellate cells | induction of expression; antagonizes TGFβ signaling | Smad7 | [153] |
 | Chronic liver disease | rat hepatoma cells (FAO) | suppression of gene transcription | Mrp2 | [206] |
 | Kidney transplant rejection | primary monocytes | activation of gene transcription | RANTES/CCL5 | [126] |
 | Kidney transplant rejection | differentiated macrophages | suppression of gene transcription | RANTES/CCL5 | [126] |
 | Neointimal hyperplasia Atherosclerosis | vascular smooth muscle cells | activation of gene transcription | RANTES/CCL5 | [127] |
 | Endometriosis | peritoneal macrophages | activation of gene transcription and recruitment of inflammatory cells | RANTES/CCL5* | |
 | Chronic kidney disease Interstial kidney disease | proximal tubular cells | control of translation | TGFβ | |
 | Mesangioproliferative glomerulonephritis | endothelial cells | gene transcription | PDGF-B | [111] |
 | Mesangioproliferative glomerulonephritis | renal cells | gene transcription, secretion | PDGF-B | [138] |
 | Tubulointerstial nephritis | renal cells, macrophages | gene transcription, secretion, differentiation, phagocytosis | RANTES/CCL5 MCP-1/CCL2 IL-10 | |
 | Dysregulated angiogenesis |  | repression of VEGF promotor | VEGF | [210] |
 | Calcineurin inhibitor mediated kidney fibrosis | mesangial cells | binding and stabilization of mRNA | Collagen | [136] |
 | Anti-Thy1.1 nephritis | mesangial cells | gene transcription, secretion | Notch-3 | [54] |
 | Type II diabetes | skeletal muscle | gene transcription, signal pathways | PTP1B | [55] |
 | T-ALL | T cell | Cell cycle | Cdk6 | [181] |
CHSP1 | Inflammation Sepsis | macrophages | enhancement of mRNA stability | TNF | [24] |
DbpA | Dysregulated angiogenesis | fibroblasts | repression of VEGF promoter | VEGF | |
 | Hepatocellular carcinoma | hepatocytes |  |  | |
 | Mesangioproliferative glomerulonephritis | renal cells | gene transcription, secretion | DbpA | [13] |