Fig. 8
From: TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation
Schematic representation of the association between uPA and its binding partners. a The interaction of TEM8 with α-enolase brings uPA and plasminogen into close proximity, resulting in a highly efficient reciprocal activation of Pro-uPA/HMW-scuPA and plasminogen at the leading edge of the migrating cell, which then breaks down ECM components or activates latent growth factors. In addition, ligation of uPA to TEM8 may directly activate uPAR-independent intracellular signal transduction pathways (such as EGFR-ERK1/2) via the long cytoplasmic tail of TEM8. b ATF-Fc and TEM8-Fc completely block the cell surface-associated proteolytic activity of uPA as well as uPA-initiated cell signaling and cytoskeletal rearrangement