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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation

Fig. 3

Association and dissociation of uPA from immobilized TEM8. A series of concentrations of HMW-scuPA, HMW-tcuPA or LMW-uPA (62.5, 125, 250, 500 and 1000 nM from bottom to top) were double-injected into a sensor chip pre-bound with approximately 5,000 resonance units of TEM8-Fc. All of the procedures were performed with running buffer in the absence of Mn2+ (Fig. 3, left side) or in the presence of 2 mM Mn2+ (Fig. 3, right side). Colored lines indicate the association and dissociation curves of the three forms of uPA with immobilized TEM8-Fc; black lines indicate the fitted curves

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