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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: MicroRNA let-7b inhibits keratinocyte differentiation by targeting IL-6 mediated ERK signaling in psoriasis

Fig. 5

Let-7b suppresses expression of IL6 in a keratinocyte-specific let-7b transgenic mouse model. a qRT-PCR analysis of IL-6 expression in lesioned skin samples from IMQ-induced wild-type mouse model. b qRT-PCR revealed down-regulation of IL6 expression in primary keratinocytes from wild-type and transgenic mice. c qRT-PCR analysis revealed IL6 level of wild-type and transgenic mice treated with IMQ at days 3 and 5. d Immunohistochemical localization of IL6 protein 5 days after mice were treated with IMQ (n = 5). Histograms represent the average ± SD from three independent assays. *P < 0.05; **P < 0.01;***P < 0.01. Scale bars, 100 μm

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Cell Communication and Signaling

ISSN: 1478-811X