Skip to main content
Fig. 2 | Cell Communication and Signaling

Fig. 2

From: KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer

Fig. 2

KLF4 upregulated BIK expression. a KLF4 WT or KO PC3 cells were treated with 20 μM cisplatin at the indicated times. Gene expression profiles were obtained by RNA sequencing analysis. b-e PC3 and DU145 cells with or without KLF4 KO were treated with 20 μM cisplatin at the indicated times. The mRNA and protein levels of BIK were analysed by q-RT-PCR and western blotting. Data represent the mean ± SD of three independent experiments. *** p < 0.001 vs. control. f-i PC3 and DU145 cells with or without KLF4 knockdown were treated with 20 μM cisplatin at the indicated times. The mRNA and protein levels of BIK were analysed by q-RT-PCR and western blotting. Data represent the mean ± SD of three independent experiments. ***p < 0.001 vs. control

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X