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Table 5 Inhibitors of FOXM1 whose mechanism has been elucidated

From: Regulation of the master regulator FOXM1 in cancer

Inhibitors Mechanism Effect Cancer cells
Thiazolidinediones Inhibit Sp1 mRNA exprssionb hepatoma [95]
Diarylheptanoids Inhibit Gli1 mRNA and protein exprssionb pancreatic cancer [96]
RCM-1 increase ubiquitination protein degradationa osteosarcoma [99]
Thiostrepton Interact with FOXM1 binding of FOXM1 to target sitesb breast cancer [98]
honokiol Interact with FOXM1 binding of FOXM1 to target sitesb osteosarcoma [100]
FDI-6 Block FOXM1 DBD binding of FOXM1 to target sitesb MCF-7[128]
FOXM1 Apt target FOXM1 DBD binding of FOXM1 to target sitesb HEK 293 T [136]
Peptide 9R-P201 target FOXM1 DBD FOXM1 and garget gene expressionb HepG2 [137]
  1. a: Promoting;
  2. b: Inhibition