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Table 3 Post-translational modifications of FOXM1

From: Regulation of the master regulator FOXM1 in cancer

PTM

Enzyme

Effect

Cell cycle

FOXM1 isoform

Phosphorylation

 T620,T627,S672

Cyclin D-CDK4/6[6]

Transcriptional activitya

stabilizationa

G1 → S

FOXM1c

 S331

Raf/MEK/MAPK [60]

Nuclear translocationa

Late S

FOXM1c

 S704

Raf/MEK/MAPK [60]

Transcriptional activitya

Late S

FOXM1c

 T600,T611,S638

Cyclin A/E-Cdk2 [62, 63]

Transcriptional activitya

G2/M

FOXM1c

 T596

Cyclin B1-Cdk1 [64]

Transcriptional activitya

G2/M

FOXM1b

 S678

Cyclin B1-Cdk1 [65]

Transcriptional activitya

Late G2

FOXM1b

 S507,S657, T585

Cyclin B1-Cdk1 [131]

Transcriptional activitya

G2/M

FOXM1b

 S715,S724

Plk1 [64]

Transcriptional activitya

G2 → M/M

FOXM1b

 S361

Chk2 [66]

stabilizationa

DDR

FOXM1b

 S251

c [59]

CDK1-dependent phosphorylationa

G2/M

FOXM1b

 S474

GSK3 [67]

degradationa

 

FOXM1b

Ubiquitination

 -

APC/C-Cdh1 [71, 72]

degradationa

Late M/Early G1

FOXM1

 -

CRL4-VprBP [73]

degradationa

G1/S

FOXM1

 -

SCF/FBXO31 [74]

degradationa

G2 → M

FOXM1

 -

SCF/FBXL2 [132]

degradationa

 

FOXM1

 -(K48)

FBXW7 [67]

degradationa

 

FOXM1

 -(K48)

RNF8,RNF168 [75]

degradationa

(DDR)

FOXM1

De-ubiquitination

 -

USP5 [67]

Nuclear translocationa

 

FOXM1

 (K48)

OTUB1 [76, 77]

degradationb

 

FOXM1

SUMOylation

 Lys132,144,201,218,356,368,415,440,443,460,478,495(SUMO2)

c [78]

Transcriptional activitya

Nuclear translocationa

G2/M

FOXM1c

 Lys463(SUMO1)

PIASy [79]

Transcriptional activitya

 

FOXM1b

 Lys201,218,460,478,495(SUMO1)

Ubc9 [80]

Cytoplasmic translocationa

Cdh1-mediated degradationa

(CDR)

FOXM1c

 -(SUMO1,2,3)

Ubc9,PIAS1 [81]

Cytoplasmic translocationa

stabilizationb

 

FOXM1b

 Lys201,218,341,445,462,480(SUMO1)

c [68]

Cytoplasmic translocationa

stabilizationb

Late M

FOXM1b

Acetylation

 Lys63,422,440,603,614

CBP/p300 [82]

stabilizationa

DNA-binding abilityaTranscriptional activitya

G2/M

FOXM1c

Methylation

 -

SETD3 [83]

Transcriptional activityb

 

FOXM1

  1. K48 Lys48-linked poly-ubiquitin chains, DDR DNA-damage response, CDR cytotoxic drug response
  2. a: Promoting
  3. b: Inhibition
  4. c: not clear
  5. → Transition