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Table 1 Factors reported to bind directly to FOXM1 promotor and regulated its expression

From: Regulation of the master regulator FOXM1 in cancer

Transcription factor Responsive element Act. / Rep. Cell Coactivator Pos. / Neg. regulation
cMyc [109, 110] E-Box A U-937 etc.   CAR [44]/−
Mxi1-SRα [45] E-Box R DL23   -/FOXO3a [111]
HIF-1α [36] −271/− 267, − 47/− 42 A HepG2   TNF-α [37]/−
ERα [42] −45 A MCF-7 ZR-75-1   -/HDACs
ERβ [43] −45 R MCF-7   
E2F [34] −24 A MCF-7   MnSOD [31]/P53 [34, 112]
STAT3 [32] −440/− 432 A K562   MAPK/−
CREB [33] −60/− 36 A HepG2   HBx/−
HSF1 [38] − 1792/− 1767 A U-87MG   
Twist1 [35] − 375/− 352 A NCI-N87 P300  
LXRa [39] −52/− 39 R HepG2   
Gli1 [9, 10] −216/− 204 A HT29   
Gli1, Gli2 [8] Not clear A Murine NSCs   
SPDEF [47] −670/− 660 R TRAMP-C2R3   
FOXM1 [46, 47] −745/− 660, − 27/− 22 A TRAMP-C2R3, MCF-7   AURKA [49]/−
CTCF [30] − 296/− 120 A HepG2   
Sp1 [95] − 891 A HepG2   
P53 [41] Not clear R mice hepatocyte   
  1. Act. /Rep. Activator or repressor, Pos. /Neg. positive or negative regulatory factor, A activate, R repress