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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Chemotherapy induced PRL3 expression promotes cancer growth via plasma membrane remodeling and specific alterations of caveolae-associated signaling

Fig. 5

PRL3 expression affects the translocation of Rac1 to the plasma membrane. (a) Western blot analysis of isolated total membranes from the indicated cells shows that PRL3 expression results in enhanced translocation of Rac1 to the plasma membrane. (b) Representative confocal images of Rac1 plasma membrane localization in PRL3-expressing cells. c Rac1 localizes to the caveolae fraction in the doxycycline-induced B16F0-PRL3 cells. (d) Rac1 coimmunoprecipitation with the major caveolae scaffold Caveolin 1 indicates that Rac1 translocate to the caveolae fraction upon PRL3 expression

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