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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Merkel cell polyomavirus and Langerhans cell neoplasm

Fig. 1

Proposed role of MCPyV in the development of LCH and LCS. We propose two distinct models for LCS and LCH pathogenesis. LCS is a malignant neoplasm initiated by MCPyV infection. On the contrary, LCH is a reactive disorder with underlying neoplastic potential. In other words, LCH is an inflammatory process that is prolonged by mutations. MCPyV: Merkel cell polyomavirus; LCH: Langerhans cell histiocytosis; LCS: Langerhans cell sarcoma; UV: ultraviolet; LC: Langerhans cell; LCH cells: CD1a-positive activated Langerhans (not atypical Langerhans cell, morphologically)-like cells in LCH lesion; LCS cells: sarcoma cells in LCS

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