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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: lncRNA KRAL reverses 5-fluorouracil resistance in hepatocellular carcinoma cells by acting as a ceRNA against miR-141

Fig. 3

KRAL expression is downregulated in 5-fluorouracil-resistant HCC cells. a Comprehensive panel of ten differentially expressed lncRNAs in HepG2/5-FU and HepG2 cells were validated by qRT-PCR. GAPDH was used as a reference, Data are expressed as the mean ± SD; columns: normalized mean of three independent experiments; *p < 0.05, **p < 0.01. b A comparison between the microarray Gene Chip and RT-PCR data in the expression (fold change, 5-FU resistance/parental) for differentially expressed lncRNAs. Columns: fold change of three independent experiments. c qRT-PCR was performed to detect the relative expression of KRAL in SMMC-7721, SMMC-7721/5-FU, HuH7, and HuH7/5-FU cells. GAPDH was used as a reference, Columns: normalized mean of three independent experiments; **p < 0.01

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