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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Wilms’ tumor 1-associating protein plays an aggressive role in diffuse large B-cell lymphoma and forms a complex with BCL6 via Hsp90

Fig. 5

Proposed model of the interplay between Hsp90, WTAP and BCL6. Hsp90 could form a complex with WTAP and BCL6 to stabilize their expression on protein level. When WTAP and BCL6 separate from Hsp90, these two proteins would be degraded by the ubiquitin-proteasome pathway. The overexpressed WTAP in DLBCL cells and tissues could promote proliferation and reduce apoptosis. The described interaction of WTAP with WT1 could also involve Hsp90. The function of the WTAP, BCL6 and Hsp90 complex, besides stabilization, could lie in the process of transcriptional activity

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Cell Communication and Signaling

ISSN: 1478-811X