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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation

Fig. 2

Kv1.3 channel blockade decreases the expression of CD25 and CD40L, but not that of CD69. CD4+ TEM cells were stimulated through the TCR with plate-bound OKT3 in the presence or absence of Vm24 or ShK (1 nM) toxins. After 24 h of culture, cells were stained for (a) CD25, (c) CD40L and (e) CD69. The histogram of a representative donor for each marker is shown. (b, d, f) Data from 3 to 6 independent experiments are shown as mean ± SEM. The color coding for histograms and bars is maintained. Significance of pairwise comparisons between groups is indicated with stars (*p < 0.05, **p < 0.01, ***p < 0.001)

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Cell Communication and Signaling

ISSN: 1478-811X