Table 2 Selection of Ras superfamily member RasGEF and RasGAP regulators. Selection of family members based on domain predictions using the SMART or Pfam databases

RasGEF family

KNDC1

YES

YES

PLCE1

YES

YES

RALGDS

YES

YES

RALGPS1

YES

YES

RALGPS2

YES

YES

RAPGEF1

YES

YES

RAPGEF2

YES

YES

RAPGEF3

YES

YES

RAPGEF4

YES

YES

RAPGEF5

YES

YES

RAPGEF6

YES

YES

RAPGEFL1

YES

YES

RASGEF1A

YES

YES

RASGEF1B

YES

YES

RASGEF1C

YES

YES

RASGRF1

YES

YES

RASGRF2

YES

YES

RASGRP1

YES

YES

RASGRP2

YES

YES

RASGRP3

YES

YES

RASGRP4

YES

YES

RGL1

YES

YES

RGL2

YES

YES

RGL3

YES

YES

RGL4

YES

YES

SOS1

YES

YES

SOS2

YES

YES

RasGAP family

DAB2IP

YES

YES

GARNL3

NO

YES

NF1

YES

YES

PLXNB1

NO

YES

RALGAPA1

NO

YES

RALGAPA2

NO

YES

RAP1GAP

NO

YES

RAP1GAP2

NO

YES

RASA1

YES

YES

RASA2

NO

YES

RASA3

NO

YES

RASA4

NO

YES

RASAL1

NO

YES

RASAL2

YES

YES

RASAL3

YES

YES

SIPA1

NO

YES

SIPA1L1

NO

YES

SIPA1L2

NO

YES

SIPA1L3

NO

YES

SYNGAP1

YES

YES

TSC2

NO

YES