Table 1 Enriched gene sets in GSEA analyses in HNSCC and breast cancer cell lines after liprin-α1 knockdown cultivated in 3D collagen I
Gene Set: HNSCC | NES | FDR q-value | FWER p-value |
|---|---|---|---|
GO cell substrate junction | 2,49 | 0.000 | 0.000 |
GO establishment of protein localization to endoplasmic reticulum | 2,47 | 0.000 | 0.000 |
GO protein localization to endoplasmic reticulum | 2,45 | 0.000 | 0.000 |
GO anchoring junction | 2,35 | 0.000 | 0.000 |
GO protein targeting to membrane | 2,2 | 0.000 | 0.001 |
GO establishment of protein localization to organelle | 2,14 | 0.001 | 0.011 |
GO regulation of vacuolar transport | 2,09 | 0.001 | 0.022 |
GO phosphatase complex | 2,08 | 0.002 | 0.025 |
GO establishment of protein localization to membrane | 2,07 | 0.002 | 0.039 |
GENE SET: Breast cancer | |||
GO negative regulation of hydrolase activity | 2,74 | 0.000 | 0.000 |
GO regulation of proteolysis | 2,54 | 0.007 | 0.006 |
GO negative regulation of peptidase activity | 2,5 | 0.008 | 0.010 |
GO regulation of peptidase activity | 2,44 | 0.008 | 0.013 |
GO membrane microdomain | 2,42 | 0.008 | 0.018 |
GO positive regulation of cell death | 2,33 | 0.016 | 0.041 |
GO morphogenesis of an epithelium | 2,32 | 0.015 | 0.044 |