Skip to main content
Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton

Fig. 4

a Immunofluorescence staining of CD82 and liprin-α1 in UT-SCC-42A cells cultured in 2D showed localization of CD82 in intracellular vesicle-like structures and at the cell membrane after liprin-α1 knockdown (shPPFIA1). Liprin-α1 was localized in invadosome structures or after the leading edge in shScr control cells. b Immunofluorescence staining of CD82 and liprin-α1 in UT-SCC-42A control (shScr) and liprin-α1 knockdown (shPPFIA1) cells in 3D culture. In shScr cell colonies, liprin-α1 was located either as cytosolic or on the edges of the cellular outgrowths in adhesion- or invadosome-like structures. ShPPFIA1 cells showed localization of CD82 mainly at the cell membrane, in cell-cell and in cell-extracellular matrix contacts. Scale bar is 10 μm, and magnification 63×

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X