Fig. 2
From: Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors
IL-15 inhibits the adipogenesis of FAPs both in vivo and in vitro. a Immunofluorescence for fatty infiltration after administration of IL-15 in injured muscles 7 dpi. Scale bars, 20 μm. b Quantifications of adipose occupied area (shown in percentage) in injured muscles 7 dpi with glycerol injection. c Real-time PCR for adipogenic biomarkers (c/ebpα, pparγ and FABP4) in whole injured muscles 7 dpi with glycerol injection. d The effect of IL-15 on adipogenesis of FAPs was detected by Oil Red O staining in vitro. Scale bars, 100 μm (top), 40 μm (bottom). e Quantifications of Oil Red O occupied area (shown in percentage). f qPCR analysis of DHH and TIMP3 in purified FAPs from injured muscles 7 dpi